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Extra resources for Advances in Immunopharmacology. Proceeding of the Fourth International Conference on Immunopharmacology, Osaka, Japan, 16–19 May 1988

Example text

After 5 weeks of withdrawal, these infiltrates remained at perivascular area. These findings may suggest that although the etiology of hepatotoxicity is unclear, prolonged administration of r-IL-2 could stimulate the extravasation of mononuclear cells into hepatic parenchyma and the release of other cytokines through unpredictable mechanism within the immune system. Then, in combination with other cytokines, r-IL-2 would harm hepatocytes and facilitate fibrosis which might cause genesis of liver cirrhosis.

These d i f f e r e n c e s are a p p a r e n t l y not structural b u t due t o a n o v e l e n z y m a t i c a c t i v i t y ( H a r b o u r , e t a l . , 1 9 8 7 ) . I n a d d i t i o n , two l a b o r a t o r i e s h a v e b e e n a b l e t o d e t e c t POMC mRNA i n s p l e n o c y t e s ( W e s t l y , e t a l . , 1986) and m a c r o p h a g e s ( L o l a i t , et a l . , 1 9 8 6 ) . I t a p p e a r s t h e n , t h a t t h e same POMC g e n e e x p r e s s e d i n p i t u i t a r y c e l l s i s a l s o i n d u c e d i n l e u k o c y t e s .

Graham) Alan R. Liss, Inc. 3-14 Harada, Y. (1987). E. Graham) Alan R. Liss, Inc. C. B. (1987). E. Graham) Alan R. Liss, Inc. , Ikeuchi, J. and Nina, N. (1986). , Nakai, K. and Harada, Y. (1986). , Yoshizaki, T. and Ikeuchi, J. (1986). J. R. (1987). C. A. (1985). J. Immunol. D. A. (1985). J. Biol. Resp. Modif. , Dawson, Α. and Harada, Y. (1986). , Dawson, A. and Harada, Y. (1986). , Dawson, A. and Harada, Y. (1986). Kiso to Rinsho (in Japanese) 20, 4175-4179 Zbinden, G. (1987). E. Graham) Alan R.

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