Cardiac Metabolism in Health and Disease - download pdf or read online

By L. M. King, L. H. Opie (auth.), Salah Abdel-Aleem, James E. Lowe (eds.)

ISBN-10: 1461376033

ISBN-13: 9781461376033

ISBN-10: 1461556872

ISBN-13: 9781461556879

This specific factor of Molecular and mobile Biochemistry includes unique learn papers in addition to invited reports centred within the box of cardiac metabolism and its rules lower than common and affliction stipulations. those papers disguise many components below extensive and quick improvement equivalent to the legislation of fatty acid oxidation within the center, the function of cardiac glycogen in the course of ischemia, the function of CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy, cardiac defense via rules of power creation, the position of fatty acid binding protein less than common and pathological stipulations, and several very important themes during this zone of analysis. we are hoping that this distinctive factor of Molecular and CellularBiochemistry offers an up to date resource of data for scientists and clinicians attracted to the mechanism during which cardiac metabolism is regulated in health and wellbeing and illness and the mechanistic courting among disturbances in cardiac metabolism and the genesis of cardiovascular diseases.

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Molecular cloning techniques have demonstrated that two CPT-I isoforms exist as genes encoding the 'muscle' and 'liver' enzymes. Regulation offatty acid oxidation rates depends on both short-term regulation of enzyme activity and long-term regulation of enzyme synthesis. Most early investigations into metabolic control offatty acid oxidation at the CPT-I step concentrated on the hepatic enzyme which can be inhibited by malonylCoA and can undergo dramatic amplification or reduction of its sensitivity to inhibition by malonyl-CoA.

Cell 83: 841-850, 1995 Park EA, Mynatt RL, Cook GA, Kahfi K: Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic camitine palmitoyltransferase-l. Biochem J 310: 853-858,1995 Asins G, Serra D, Arias G, Hegardt FG: Developmental changes in camitine palmitoyltransferase I and II genes during development in the rat. Biochem J 306: 379-384, 1995 Hudson EK, Liu MH, Buja LM, McMillin 18: Insulin-associated changes in carnitine palmitoyltransferase in cultured neonatal rat cardiac myocytes.

Biochem J 206: 177-179,1982 15. Cook GA: Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in K. values. J Bioi Chern 259: 12030--12033,1984 ' 16. Cook GA, Gamble MS: Regulation of camitine palmitoyltransferase by insulin results in decreased activity and decreased apparent ~ values for malonyl-CoA. J Bioi Chern 262: 2050--2055, 1987 17. Mynatt RL, Greenhaw JJ, Cook GA: Cholate extracts ofmitochondrial oUler membranes increase malonyl-Co A inhibition of caroitine palmitoyltransferase-I by a mechanism involving phospholipids.

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Cardiac Metabolism in Health and Disease by L. M. King, L. H. Opie (auth.), Salah Abdel-Aleem, James E. Lowe (eds.)

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