By Ciba Foundation
Chapter 1 Chairman's establishing comments (pages 1–4): Arnold R. Rich
Chapter 2 The Proteins of the Tubercle Bacillus (pages 5–13): M. Stacey
Chapter three Chemical constitution and organic job of Mycolic Acids (pages 14–40): J. Asselineau and E. Lederer
Chapter four Mycobactin: A progress issue for Acid?Fast Bacilli (pages 41–54): F. L. Rose and G. A. Snow
Chapter five Polysaccharide parts of the Tubercle Bacillus (pages 55–68): M. Stacey
Chapter 6 Granuloma?Producing homes of artificial Fatty Acids (pages 69–86): J. Ungarm
Chapter 7 Early Tissue Reactions to Tubercle bacilli and Their items (pages 87–101): A. A. Miles
Chapter eight Succinic Dehydrogenase job in Tuberculous Animals (pages 102–114): S.P. Martin, S.N. Chaudhuri, C.D. Cooper and R. Green
Chapter nine Biochemical components that could impact the destiny of Tubercle Bacilli in Tissues (pages 115–130): James G. Hirsch
Chapter 10 Bacterial parts involved within the Early section of an infection (pages 131–143): Hubert Bloch
Chapter eleven Serological task of varied Fractions of tradition Filtrates of the Tubercle Bacillus (pages 144–162): Stephen V. Boyden and Ernst Sorkin
Chapter 12 The Serology of Tubercle Polysaccharides (pages 163–173): C. N. Iland and D.B. Peacock
Chapter thirteen The Chemical Nature of the Lipoidal issue of the Tubercle Bacillus liable for the Induction of Tuberculous allergic reaction (pages 174–187): S. Raffei, J. Asselineaud. and E. Ledererd
Chapter 14 Tubercle Bacilli as Immunological Adjuvants (pages 188–197): R. L. Mayer
Chapter 15 Relation among progress Inhibitory estate of Monocytes for Tubercle Bacilli and allergy to Tuberculin: An in vitro learn (pages 198–210): Emanuesl Suter
Chapter sixteen Tuberculous allergic reaction and Desensitization (pages 211–224): George Brownlede and D. G. Madigan
Chapter 17 Tubercle Bacilli in contaminated Tissues Grown on Tissue tradition (pages 225–236): E. M. Brieger
Chapter 18 The function of Bacterial Multiplication within the institution of Immunity to Tuberculosis (pages 237–245): Hubert Bloch
Chapter 19 at the Mode of motion of Cortisone at the Pathogenesis of Tuberculosis and its Implications for the character of Genetic Resistance to the illness (pages 246–260): Max B. Lurie and Peter Zappasodi
Chapter 20 The Mechanism curious about obtained Immunity to Tuberculosis (pages 261–282): Sidney Raffel
Chapter 21 Human Lung Tissue Reactions to the Tubercle Bacillus relating to Chemotherapy (pages 283–298): Georges Canetti
Chapter 22 impression of yes Surface?Active brokers at the Host?Parasite dating in Experimental Tuberculosis (pages 299–310): P. D'Arcy Hart and R. J. W. Rees
Chapter 23 the connection among the expansion requisites and the Pathogenicity of Isoniazid?Resistant Mutants of Tubercle Bacilli: A learn of the function of Host body structure in Susceptibility to Infectious ailment (pages 311–339): G. Middlebrook
Chapter 24 A Pathogenetic dating among Tuberculosis and Leprosy: the typical Denominators within the Tissue reaction to Mycobacteria (pages 340–343): Max B. Lurie
Chapter 25 The Leprosy Bacillus and the Host response to It (pages 344–354): J. Lowe
Chapter 26 The response of the Host Tissue relating to Mycobacterium lepr? (pages 355–363): R. G. Cochrane
Chapter 27 Immunological and Physiological foundation of Immunization in Tuberculosis and Leprosy (pages 364–387): John H. Hanks
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Content material: bankruptcy 1 Chairman's beginning feedback (pages 1–4): Arnold R. RichChapter 2 The Proteins of the Tubercle Bacillus (pages 5–13): M. StaceyChapter three Chemical constitution and organic task of Mycolic Acids (pages 14–40): J. Asselineau and E. LedererChapter four Mycobactin: A progress issue for Acid?
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Extra info for Ciba Foundation Symposium - Experimental Tuberculosis: Bacillus and Host (with an Addendum on Leprosy)
P. p. 75")' and have found persistent necrotic lesions with formation of giant cells: some difference seems to exist between the action of low melting and high melting human mycolic acids. After intraperitoneal injections of 80 mg. of methyl 3-hydroxy-x-methoxymycolanoate [I-Test] to a guinea pig (ether as vehicle), Barry (1949) has found neither macro- nor microscopical abnormalities. These discrepancies may be due to the acidity of the former products or to the better state of dispersion of the latter.
P. p. 85-88"). These ketones have lost the two asymmetric centres a t carbon atoms 2 and 3 of the parent mycolic acids (Asselineau, Ganz and Lederer, 1951). (2) As both a- and 8-mycolic acids are dextrorotatory, a diastereoisomerism concerning the a- and 8-carbon atoms could only be possible if one acid were the (+)threo and the other the (+) erythro form. This does not seem to be the case, as the above-mentioned experiments with synthetic - 28 J. ASSELINEAU AND E. LEDERER racemic corynomycolic acid show, that the threo form is lower melting, more soluble and more difficult to elute, whereas with the a- and 8-mycolic acids of Mycobacteria the more easily eluted isomer is the lower melting and more soluble one.
Miscellaneous: Waksman and Adams (1953) have observed that tubercle bacillus lipopolysaccharides (Pmko, Anderson's purified wax) are active in the production of experimental allergic encephalomyelitis in rabbits, when injected together with rabbit spinal cord. These lipid fractions play the same r6le as tubercle bacillary bodies in previous *We have shown the similarity of Pmko (human strain PB-15) to the lipopolysaccharide (wax D) of the human strain Test (Asselineau, 1951). 36 J. ASSELINEAU AND E.
Ciba Foundation Symposium - Experimental Tuberculosis: Bacillus and Host (with an Addendum on Leprosy) by Ciba Foundation