Download e-book for kindle: Control of membrane function: Short-term and long-term by J. Murdoch Ritchie, Pierre J. Magistretti and Liana Bolis

By J. Murdoch Ritchie, Pierre J. Magistretti and Liana Bolis (Eds.)

ISBN-10: 0444811257

ISBN-13: 9780444811257

A severe consider cell-to-cell interactions is the presence within the mobilephone membrane of hugely particular ion channels managed through particular receptors which are certain to, and activated by means of, a gamut of exterior hormones and neurotransmitters. via either this motion on ion channels, and motion on different membrane elements (such as G-proteins), extracellular signs regulate intracellular occasions, frequently throughout the mediation of moment messengers, and so give you the foundation for the transduction mechanism connecting extracellular signs with intracellular effectors. This quantity offers with some of the ways in which such membrane functionality is managed

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54) W - 0 . 46) Ο 200 ο 300 200 Ε 1 2 3 4 Open time (ms) 5 1 2 3 4 Open time (ms) Figure 6. Effect of NA on the gating of unitary N-type Ca channels, a, b, Sequential sweeps of N-type Ca channel currents recorded in two cell-attached patches, in the absence of NA (a) and with 30 μΜ NA present in the pipette solution (b). 02pA fn = 5), but did offect gating kinetics, c, d, Histograms of open time durations measured from the patches illustrated in a & b. The smooth curve is the sum of two exponentials fitted by least-squares to the histogram data.

Concentrations of C G R P in 7 the 10 ~ M range were effective, and the maximal effect was achieved within 5 - 8 min after application of C G R P . Single-channel electrophysiological recordings from myotubes indicated that neither the mean channel open time nor the channel current amplitude was affected by C G R P , but rather that the frequency of channel openings was reduced. This effect of C G R P could be mimicked by forskolin or c A M P . Maximal doses of forskolin and C G R P together were not additive in their effects on increasing the A C h R desensitization rate, arguing that C G R P and forskolin use the same biochemical pathway to achieve this altered physiological behavior of the ion channel.

Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sei U S A 81: 1 5 5 - 159. Fontaine B, Klarsfeld A , Hokfelt T, Changeux J-P (1986). Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes. Neurosci Lett 71: 5 9 - 6 5 . Giraudat J, Dennis M, Heidmann Τ, Chang J-Y, Changeux J-P (1986). Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptors: serine-262 of the δ is labeled 3 by [ H] chlorpromazine.

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Control of membrane function: Short-term and long-term by J. Murdoch Ritchie, Pierre J. Magistretti and Liana Bolis (Eds.)

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